Benchmarking is not validation

Clinical genomics runs on research-grade code. We need to validate it.

Aug 11 • Nils Homer

A CRISPR off-target search is only as good as the sequences it searches

Rebuilding DivRef so CRISPR off-target searches can account for human variation

Aug 5 • Alison Meynert

July 2026

Why CRISPR Off-Target Search Should Report Multiple Alignments Per Locus

How Sassy enumerates every reasonable alignment without sacrificing runtime

Jul 21 • Tim Dunn

June 2026

Minibwa: alignment is never solved

Heng Li and Nils Homer revisit BWA-MEM with a faster mapper for short reads, accurate long reads, and bisulfite sequencing data.

Jun 30

Bioinformatics Still (Mostly) Runs on Old Plumbing

Some of the most valuable work happens in the tools underneath the tools

Jun 17 • Tim Fennell

April 2026

Deep QC Should Run on Every Sequencing Dataset. That’s Why I Built Riker.

The case for rebuilding sequencing QC instead of carrying old performance costs forward

Apr 21 • Tim Fennell

Ambient DNA Preservation Without Compromising Sequencing: Our Role in Evaluating Ensilication

Whole‑genome analysis of storage-induced artifacts in tumor and normal DNA

Apr 8

March 2026

Introducing fgumi

A New UMI Toolkit for Next-Gen Sequencing

Mar 31

What Human Genome Is This, Really?

Every bioinformatician has been there.

Mar 24

Introducing ferro-hgvs

Faster, more complete HGVS variant parsing for the whole genomics community

Mar 20

Your Bioinformatics Tools Need to be AI-Ready

If you're not building tools that emit rich data for machine learning, you're wasting your compute.

Mar 16 • Nils Homer

February 2026

fastquorum: Making UMI consensus boring (in the best way)

If you’ve worked with UMI-tagged sequencing data long enough, you already know the theory.

Feb 16